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Review
. 2003 May;11(5):1129-38.
doi: 10.1016/s1097-2765(03)00191-6.

Early formation of mRNP: license for export or quality control?

Torben Heick Jensen  1 , Ken Dower, Domenico Libri, Michael Rosbash
Affiliations
Free article
Review

Early formation of mRNP: license for export or quality control?

Torben Heick Jensen et al. Mol Cell. 2003 May.
Free article

Abstract

Eukaryotic mRNA is processed by enzymes and packaged with proteins within nuclei to generate functional messenger ribonucleoprotein (mRNP) particles. Processing and packaging factors can interact with mRNA cotranscriptionally to form an early mRNP. Erroneous mRNP formation leads to nuclear retention and degradation of the mRNA. It therefore appears that one function of cotranscriptional mRNP assembly is to discard aberrant mRNPs early in their biogenesis. Cotranscriptional mRNP assembly may also enable the transcription machinery to respond to improper mRNP formation.

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