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Review
. 2003 May 27;168(11):1439-42.

Serotonin syndrome: a brief review

Philippe Birmes  1 , Dominique Coppin, Laurent Schmitt, Dominique Lauque
Affiliations
Review

Serotonin syndrome: a brief review

Philippe Birmes et al. CMAJ. .
No abstract available

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Figures

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Fig. 1: Mechanisms of serotonin syndrome. (1) Increased doses of L-tryptophan will proportionally increase 5-hydroxytryptamine (5-HT or serotonin) formation. (2) Amphetamines and other drugs increase the release of stored serotonin. (3) Inhibition of serotonin metabolism by monoamine oxidase (MAO) inhibitors will increase presynaptic 5-HT concentration. (4) Impairment of 5-HT transport into the presynaptic neuron by uptake blockers (e.g., selective serotonin reuptake inhibitors, tricyclic antidepressants) increases synaptic 5-HT concentration. (5) Direct serotonin agonists can stimulate postsynaptic 5-HT receptors. (6) Lithium increases postsynaptic receptor responses. Adapted with permission from Elsevier Science (Critical Care Clinics 1997;13[4]:763-83). Photo: Chesley Sheppard
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References

    1. Stalh SM. Essential psychopharmacology. Neuroscientific basis and practical applications. 2nd ed. Cambridge: Cambridge University Press; 2000.
    1. Mason PJ, Morris VA, BalcezaK TJ. Serotonin syndrome. Presentation of 2 cases and review of the literature. Medicine 2000;79:201-9. - PubMed
    1. Jaunay E, Gaillac V, Guelfi JD. Syndrome sérotoninergique. Quel traitement et quand? Presse Med 2001;30:1695-700. - PubMed
    1. Gillman PK. The serotonin syndrome and its treatment. J Psychopharmacol 1999; 13:100-9. - PubMed
    1. Oates JA, Sjoerdsma A. Neurologic effects of tryptophan in patients receiving monoamine oxidase inhibitor. Neurology 1960;10:1076-8. - PubMed

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