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. 2003 Jun;84(Pt 6):1443-1450.
doi: 10.1099/vir.0.19054-0.

Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV

Orlando de Jesus  1 , Paul R Smith  1 , Lindsay C Spender  1 , Claudio Elgueta Karstegl  1 , Hans Helmut Niller  2 , Dolly Huang  3 , Paul J Farrell  1
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Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV

Orlando de Jesus et al. J Gen Virol. 2003 Jun.

Abstract

Two sequences required for activity of the Epstein-Barr virus BART RNA promoter in transfection assays have been identified by site-directed mutagenesis. One contains a consensus AP-1 site; the other has some similarity to Ets and Stat consensus binding sites. Candidate sequences were suggested by mapping a region of unmethylated DNA in EBV around the BART promoter followed by in vivo footprinting the promoter in the C666-1 nasopharyngeal carcinoma cell line, which expresses BART RNAs. The data are presented in the context of a revised EBV DNA sequence, known as EBV wt, that is proposed as a future standard sequence for EBV.

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