Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2003 May 19;88(10):1570-7.
doi: 10.1038/sj.bjc.6600918.

Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients

K-U Petry  1 , S Menton, M Menton, F van Loenen-Frosch, H de Carvalho Gomes, B Holz, B Schopp, S Garbrecht-Buettner, P Davies, G Boehmer, E van den Akker, T Iftner
Affiliations
Clinical Trial

Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients

K-U Petry et al. Br J Cancer. .

Abstract

In a prospective cohort study 8466 women attending routine cervical cancer screening were recruited. Colposcopy was performed on women with any degree of atypia on cytology and/or a positive high-risk human papillomavirus (HPV)-DNA test (HC2; Hybrid Capture 2((c))), and for a randomly selected sample of 3.4% women with negative findings on both. Quality control included reviews of cytology, histology, colposcopy images and retesting of samples with polymerase chain reaction. Test diagnostic performances were based on 7908 women who had complete baseline and follow-up results. Routine histology identified 86 women with high-grade cervical intraepithelial neoplasia (CIN2+), which was confirmed by review histology in only 46 cases. Sensitivity of routine cytology for the detection of CIN2+ was 43.5%, with a specificity, positive predictive value (PPV), negative predictive value (NPV) of 98.0, 11.4 and 99.7%, respectively. Sensitivity of the HC2 test for the detection of CIN2+ was 97.8%, with a specificity, PPV and NPV, of 95.3, 10.9 and 100%, respectively. No high-grade neoplasia was detected in the randomly selected control group. A negative HPV-test result, even in combination with a positive Papanicolaou (Pap) result, virtually excluded any risk of underlying high-grade disease, but this was not the case for a negative Pap result. These data show that HPV testing is of value for the detection or exclusion of prevalent CIN in a routine cervical cancer-screening setting and could be used for further risk classification of women for follow-up management.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Study Protocol.
Figure 2
Figure 2
Patients grouped by cytology, HPV-test results and their confirmed histology results.
Figure 3
Figure 3
Patients divided into four groups according to their cytology and HPV test, follow-up management and confirmed histology results.
See this image and copyright information in PMC

References

    1. Bosch XF, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R, Shah KV (1995) Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 87: 796–802 - PubMed
    1. Clavel C, Masure M, Bory JP, Putaud I, Mangeonjean C, Lorenzato MNP, Gabriel R, Quereux C, Birembaut P (2001) Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women. Br J Cancer 84: 1616–1623 - PMC - PubMed
    1. Cuzick J, Beverley E, Ho L, Terry G, Sapper H, Mielzynska I, Lörincz A, Chan WK, Krausz T, Soutter WP (1999) HPV testing in primary screening of older women. Br J Cancer 81: 554–558 - PMC - PubMed
    1. Evander M, Edlund K, Gustafsson A, Jonsson M, Karlsson R, Rylander E, Wadell G (1995) Human papillomavirus infection is transient in young women: a population-based cohort study. J Infect Dis 171: 1026–1030 - PubMed
    1. Ferlay J, Parkin DM, Pisani Pe (1988) EUCAN Database: Cancer Incidence and Mortality in Europe. International Agency for Research on Cancer–World Health Organisation. IARC Press: Lyon

Publication types

MeSH terms