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Comparative Study
. 1976 Aug;36(8):2863-7.

In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells

P A Jones, W E Laug, A Gardner, C A Nye, L M Fink, W F Benedict
  • PMID: 1277196
Comparative Study

In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells

P A Jones et al. Cancer Res. 1976 Aug.

Abstract

Various potential in vitro correlates of malignancy were studied in four chemically transformed C3H/10T1/2 Clone 8 mouse cell lines and were compared with controls cells. The degree of tumorigenicity was best predicted by the relative plating efficiencies of the morphologically transformed cells in soft agar. All transformed cells also showed an increase in extracellular fibrinolytic activity which may be an additional marker for transformation. Intracellular fibrinolytic activity and loss of 125I-labeled cell surface protein (M.W. 250,000) were not correlated with morphological transformation or tumorigenicity in these cells.

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