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Review
. 2003 Jun;31(Pt 3):497-501.
doi: 10.1042/bst0310497.

Electron transfer in human cytochrome P450 reductase

A Gutierrez  1 , A Grunau, M Paine, A W Munro, C R Wolf, G C K Roberts, N S Scrutton
Affiliations
Review

Electron transfer in human cytochrome P450 reductase

A Gutierrez et al. Biochem Soc Trans. 2003 Jun.

Abstract

Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.

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