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Review
. 2003 Jun;3(6):472-82.
doi: 10.1038/nri1110.

Lysosomal cysteine proteases regulate antigen presentation

Karen Honey  1 , Alexander Y Rudensky
Affiliations
Review

Lysosomal cysteine proteases regulate antigen presentation

Karen Honey et al. Nat Rev Immunol. 2003 Jun.

Abstract

Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.

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