Clinical Trial
doi: 10.1055/s-2003-39602.
Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD)
Affiliations
- PMID: 12776228
- DOI: 10.1055/s-2003-39602
Item in Clipboard
Clinical Trial
Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD)
Neuropediatrics.
2003 Apr.
Abstract
Adults suffering from Attention Deficit Hyperactivity Disorder (ADHD) are known to have disturbed central dopaminergic transmission. With Single Photon Emission Computed Tomography (SPECT) we studied brain dopamine transporter and receptor activity in six boys with ADHD. Three months after initiation of treatment with methylphenidate we found a down-regulation of the post-synaptic dopamine receptor with a maximum of 20 % and a down-regulation of the dopamine transporter with a maximum of 74.7 % in the striatal system. This corresponded to a positive clinical response evaluated by neuropsychological questionnaires and tests. We suggest that dopamine transporter imaging by SPECT might be used to monitor psychostimulant treatment in children suffering from ADHD.
Similar articles
-
Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder.J Clin Psychopharmacol. 2008 Jun;28(3 Suppl 2):S46-53. doi: 10.1097/JCP.0b013e318173312f. J Clin Psychopharmacol. 2008. PMID: 18480677 Review.
-
Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit/ hyperactivity disorder: positive effect of methylphenidate.J Neurol. 2002 Aug;249(8):1116-8. doi: 10.1007/s00415-002-0746-9. J Neurol. 2002. PMID: 12420715 No abstract available.
-
The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate.Eur Neuropsychopharmacol. 2005 Jan;15(1):95-101. doi: 10.1016/j.euroneuro.2004.06.004. Eur Neuropsychopharmacol. 2005. PMID: 15572278 Clinical Trial.
-
Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder.Arch Gen Psychiatry. 2007 Aug;64(8):932-40. doi: 10.1001/archpsyc.64.8.932. Arch Gen Psychiatry. 2007. PMID: 17679638
-
[Neuropsychiatric bases of the methylphenidate-therapy of the attention deficit/hyperactivity disorder (ADHD)].Fortschr Neurol Psychiatr. 2007 May;75(5):275-84. doi: 10.1055/s-2006-932179. Epub 2006 Nov 17. Fortschr Neurol Psychiatr. 2007. PMID: 17443438 Review. German.
Cited by
-
A systematic review of the potential effects of medications and drugs of abuse on dopamine transporter imaging using [123I]I-FP-CIT SPECT in routine practice.Eur J Nucl Med Mol Imaging. 2023 Jun;50(7):1974-1987. doi: 10.1007/s00259-023-06171-x. Epub 2023 Feb 27. Eur J Nucl Med Mol Imaging. 2023. PMID: 36847827 Free PMC article.
-
Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET.Synapse. 2008 Dec;62(12):950-2. doi: 10.1002/syn.20565. Synapse. 2008. PMID: 18798297 Free PMC article. No abstract available.
-
Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro.J Neural Transm (Vienna). 2006 Dec;113(12):1927-34. doi: 10.1007/s00702-006-0487-5. Epub 2006 Jun 1. J Neural Transm (Vienna). 2006. PMID: 16736241
-
The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD.Exp Brain Res. 2005 Jun;163(3):352-60. doi: 10.1007/s00221-004-2180-y. Epub 2005 Jan 15. Exp Brain Res. 2005. PMID: 15654584
-
Responsivity of the Striatal Dopamine System to Methylphenidate-A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder.Front Psychiatry. 2022 Apr 14;13:804730. doi: 10.3389/fpsyt.2022.804730. eCollection 2022. Front Psychiatry. 2022. PMID: 35492708 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
