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. 2003 May 6;88(9):1400-2.
doi: 10.1038/sj.bjc.6600923.

Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D A Tonetti  1 , M Morrow, N Kidwai, A Gupta, S Badve
Affiliations

Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D A Tonetti et al. Br J Cancer. .

Abstract

We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCalpha expression in clinical specimens was determined by comparing PKCalpha expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCalpha expression may predict TAM treatment failure.

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Figures

Figure 1
Figure 1
Protein kinase C alpha immunohistochemical staining of representative patient tumours. (A, B) Matched primary and recurrent biopsies from patient #10. (C) Primary biopsy from patient #4 exhibiting no disease recurrence. Magnification × 40.
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