Review
[Proteins regulating neurotransmitter release of synaptic vesicles at nerve terminals]
[Article in
Chinese]
Affiliations
- PMID: 12778801
Item in Clipboard
Review
[Proteins regulating neurotransmitter release of synaptic vesicles at nerve terminals]
[Article in
Chinese]
Sheng Li Ke Xue Jin Zhan.
2003 Jan.
Abstract
Neurotransmitter release of synaptic vesicle at nerve terminals is a complicated and elaborately regulated process, involving a cascade of protein-protein interactions. The SNARE core complex consisting of synaptobrevin/VAMP (a synaptic-terminal protein), syntaxin and SNAP-25 (synaptic membrane-associated proteins), acts as the membrane fusion machinery and plays essential roles in synaptic vesicle exocytosis. This review will discuss proteins with potential roles in synaptic vesicle exocytosis by regulating assembly, disassembly and the function of SNARE complex, and sum up the molecular model of vesicle exocytosis.
Similar articles
-
Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion.Nature. 2002 Feb 7;415(6872):646-50. doi: 10.1038/415646a. Nature. 2002. PMID: 11832947
-
[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis].Tanpakushitsu Kakusan Koso. 2002 Jun;47(7):794-800. Tanpakushitsu Kakusan Koso. 2002. PMID: 12058476 Review. Japanese. No abstract available.
-
Protein-protein interactions in neurotransmitter release.Neurosci Res. 2000 Mar;36(3):175-82. doi: 10.1016/s0168-0102(99)00128-5. Neurosci Res. 2000. PMID: 10683521 Review.
-
Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):289-97. doi: 10.1098/rstb.1999.0380. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10212477 Free PMC article. Review.
-
Protein interactions implicated in neurotransmitter release.J Physiol Paris. 1998 Apr;92(2):129-33. doi: 10.1016/S0928-4257(98)80150-2. J Physiol Paris. 1998. PMID: 9782456 Review.
Cited by
-
Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases.Oxid Med Cell Longev. 2022 Jul 25;2022:9176923. doi: 10.1155/2022/9176923. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35923862 Free PMC article. Review.