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. 2003 Mar;53(3):117-9.

Chromosomal abnormalities as a cause of recurrent abortions: a hospital experience

M Azim  1 , A H Khan, Z L Khilji, J A Pal, M Khurshid
Affiliations
  • PMID: 12779028

Chromosomal abnormalities as a cause of recurrent abortions: a hospital experience

M Azim et al. J Pak Med Assoc. 2003 Mar.

Abstract

Objective: To analyze the chromosomal abnormalities in couples with history of recurrent abortions.

Design: Retrospective study.

Setting: Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan.

Patients: Three hundred couples with history of recurrent abortions.

Main outcome measure: Structural chromosomal abnormalities in carrier couples.

Results: G-banded chromosomes were analyzed from both partners of 300 couples who had had two or more spontaneous abortions. Sixteen (5.3%) couples showed a chromosomal aberration in one of the partners. Seven translocations, 5 inversions, 2 deletions and 2 sex chromosomal abnormalities were identified. There was an increase in structural aberations, which was not significantly different from that reported worldwide.

Conclusion: Chromosomal analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage.

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