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. 2003 Jun;121(5):768-71.
doi: 10.1046/j.1365-2141.2003.04345.x.

Thalidomide and dexamethasone for resistant multiple myeloma

Athanasios Anagnostopoulos  1 , Donna Weber, Kim Rankin, Kay Delasalle, Raymond Alexanian
Affiliations

Thalidomide and dexamethasone for resistant multiple myeloma

Athanasios Anagnostopoulos et al. Br J Haematol. 2003 Jun.

Abstract

Between November 1998 and April 2000, the combination of thalidomide and dexamethasone was evaluated in 47 consecutive patients with multiple myeloma that was resistant to prior high-dose dexamethasone-based therapies. Remission was observed in 22 patients (47%), including six patients with complete remission. Side-effects were frequent, mild and usually reversible, but deep vein thrombosis occurred in 8% of patients. Survival and remission times were longer among patients treated for previous resistant disease rather than for resistant relapse. This experience supports the use of thalidomide-dexamethasone in myeloma patients with resistant disease and justifies further trials in newly diagnosed patients.

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