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. 2003 Jun 16;13(12):1959-61.
doi: 10.1016/s0960-894x(03)00357-3.

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

Robert Aslanian  1 , Mwangi wa Mutahi, Neng-Yang Shih, John J Piwinski, Robert West, Shirley M Williams, Susan She, Ren-Long Wu, John A Hey
Affiliations

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

Robert Aslanian et al. Bioorg Med Chem Lett. .

Abstract

Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.

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