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Review
. 2003 May;3(5):414-7.
doi: 10.1016/s1535-6108(03)00115-6.

Targeting oncogene dependence and resistance

Sunil R Hingorani  1 , David A Tuveson
Affiliations
Free article
Review

Targeting oncogene dependence and resistance

Sunil R Hingorani et al. Cancer Cell. 2003 May.
Free article

Abstract

Our expanding experience with imatinib mesylate provides instructive lessons on the power and pitfalls of targeted therapy. The often impressive initial clinical responses seen with imatinib in a variety of malignancies inevitably give way to the emergence of resistant disease. Recent findings reveal several mechanisms of resistance and suggest ways to overcome them.

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