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. 1976 May;37(1):203-6.
doi: 10.1016/0014-2999(76)90024-8.

Dopamine metabolism in the nucleus accumbens: the effect of clozapine

S Wilk, S D Glick

Dopamine metabolism in the nucleus accumbens: the effect of clozapine

S Wilk et al. Eur J Pharmacol. 1976 May.

Abstract

Dopamine metabolism in the nucleus accumbens of the rat was studied by gas chromatographic quantitation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). The ratio of DOPAC/HVA in the nucleus accumbens was significantly greater than the same ratio in the striatum. Dose-response curves for the increase in DOPAC and HVA in the nucleus accumbens and striatum 2 h after clozapine were generated. The effect of clozapine on dopamine metabolism was similar in both structures.

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