doi: 10.1016/0014-2999(76)90026-1.
Calcium influx and postjunctional supersensitivity in guinea pig aortic strips
- PMID: 1278243
- DOI: 10.1016/0014-2999(76)90026-1
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Calcium influx and postjunctional supersensitivity in guinea pig aortic strips
Eur J Pharmacol.
1976 May.
Abstract
Both reserpine and 6-hydroxydopamine (6-OHDA) pretreatment potentiated the sensitivity of guinea pig aortic strips to norepinephrine (NE), barium, methoxamine and potassium indicating postjunctional supersensitivity. However, cocaine treatmetn only potentiated the NE response indicating prejunctional supersensitivity. 6-OHDA and reserpine-induced supersensitivity but not cocaine-induced supersensitivity was accompanied by an increase in 45Ca influx.
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