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. 2003 Jun 1;63(11):2723-7.

Magnetic resonance molecular imaging of the HER-2/neu receptor

Dmitri Artemov  1 , Noriko Mori, Rajani Ravi, Zaver M Bhujwalla
Affiliations
  • PMID: 12782573

Magnetic resonance molecular imaging of the HER-2/neu receptor

Dmitri Artemov et al. Cancer Res. .

Abstract

The HER-2/neu receptor is a member of the epidermal growth factor family and is amplified in multiple cancers. It is under intense investigation both as a prognostic marker and for therapy, using monoclonal antibodies targeted against the receptor. We have developed a novel two-component gadolinium-based MR contrast agent to image the HER-2/neu receptor. Positive T1 contrast in MR images was generated by the specific binding of avidin-gadolinium complexes to tumor cells prelabeled with a biotinylated anti-HER-2/neu antibody. Significant intensity enhancement was observed in HER-2/neu-expressing cell lines and in vivo in a breast cancer model. Potential applications of this approach may include determination of the HER-2/neu status for prognosis and for selecting tumors for monoclonal antibody therapy.

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