Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?
- PMID: 1278305
- DOI: 10.1007/BF01990181
Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?
Abstract
Beta-(4-chlorophenyl)-GABA (Baclofen, Lioresal) antagonized the excitant actions of acetylcholine and substance P to comparable extents. L-glutamate-induced excitation was affected to a lesser extent. These findings do not support the suggestion that beta-(4-chlorophenyl)-GABA is a specific substance P antagonist.
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