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Editorial

. 2003 Jun;56(6):423-5.

doi: 10.1136/jcp.56.6.423.

Immune escape mechanisms in ALCL

J J Oudejans, R L ten Berge, C J L M Meijer

PMID: 12783967
PMCID: PMC1769972
DOI: 10.1136/jcp.56.6.423

Editorial

Immune escape mechanisms in ALCL

J J Oudejans et al. J Clin Pathol. 2003 Jun.

. 2003 Jun;56(6):423-5.

doi: 10.1136/jcp.56.6.423.

Authors

J J Oudejans, R L ten Berge, C J L M Meijer

PMID: 12783967
PMCID: PMC1769972
DOI: 10.1136/jcp.56.6.423

No abstract available

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Figures

Figure 1
Schematic representation of cytotoxic T lymphocyte (CTL) induced apoptosis signalling pathways. When released into the cytoplasm of the target cell, granzyme B can activate caspase 3, both directly and indirectly, by truncation of the proapoptotic bcl-2 family member Bid (t-Bid), resulting in activation of the caspase 9 mediated pathway. Ligation of the FAS death receptor by CTL secreted FAS ligand will result in activation of caspase 8, again resulting in activation of caspase 3 with execution of apoptosis.

See this image and copyright information in PMC

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References

1. Jaffe ES, Harris NL, Stein H, et al. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organisation classification of tumours. Lyon: IARC Press, 2001.
1. ten Berge RL, Dukers DF, Oudejans JJ, et al. Adverse effects of activated cytotoxic T lymphocytes on the clinical outcome of nodal anaplastic large cell lymphoma. Blood 1999;93:2688–96. - PubMed
1. Falini B, Pileri S, Zinzani PL, et al. ALK+ lymphoma: clinico-pathological findings and outcome. Blood 1999;93:2697–706. - PubMed
1. Gascoyne RD, Aoun P, Wu D, et al. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood 1999;93:3913–21. - PubMed
1. Pulford K, Falini B, Banham AH, et al. Immune response to the ALK tyrosine kinase in patients with anaplastic large cell lymphoma. Blood 2000;96:1605–7. - PubMed

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