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Editorial
. 2003 Jun;56(6):423-5.
doi: 10.1136/jcp.56.6.423.

Immune escape mechanisms in ALCL

J J Oudejans, R L ten Berge, C J L M Meijer
Editorial

Immune escape mechanisms in ALCL

J J Oudejans et al. J Clin Pathol. 2003 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of cytotoxic T lymphocyte (CTL) induced apoptosis signalling pathways. When released into the cytoplasm of the target cell, granzyme B can activate caspase 3, both directly and indirectly, by truncation of the proapoptotic bcl-2 family member Bid (t-Bid), resulting in activation of the caspase 9 mediated pathway. Ligation of the FAS death receptor by CTL secreted FAS ligand will result in activation of caspase 8, again resulting in activation of caspase 3 with execution of apoptosis.
See this image and copyright information in PMC

References

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    1. Pulford K, Falini B, Banham AH, et al. Immune response to the ALK tyrosine kinase in patients with anaplastic large cell lymphoma. Blood 2000;96:1605–7. - PubMed

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