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Review
. 2002;23(5-6):397-407.
doi: 10.1023/a:1023450204528.

Optical tweezers stretching of chromatin

Lisa H Pope  1 , Martin L Bennink, Jan Greve
Affiliations
Review

Optical tweezers stretching of chromatin

Lisa H Pope et al. J Muscle Res Cell Motil. 2002.

Abstract

Recently significant success has emerged from exciting research involving chromatin stretching using optical tweezers. These experiments, in which a single chromatin fibre is attached by one end to a micron-sized bead held in an optical trap and to a solid surface or second bead via the other end, allows manipulation and force detection at a single-molecule level. Through force-induced stretching of chromatin, mechanical properties, specific intermolecular bond strengths and DNA-protein association and dissociation kinetics have been determined. These studies will be extremely fruitful in terms of understanding the function of chromatin structure and its dynamics within the cell.

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