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. 2003 May 28;125(21):6382-3.
doi: 10.1021/ja029504i.

Simulation of pore formation in lipid bilayers by mechanical stress and electric fields

D Peter Tieleman  1 , Hari Leontiadou, Alan E Mark, Siewert-Jan Marrink
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Free article

Simulation of pore formation in lipid bilayers by mechanical stress and electric fields

D Peter Tieleman et al. J Am Chem Soc. .
Free article

Abstract

We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm.

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