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. 2003 Jul;87(1):21-5.
doi: 10.1016/s0378-8741(03)00104-1.

Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats

Mhamed Maghrani  1 , Ahmed Lemhadri, Hassan Jouad, Jean-Baptiste Michel, Mohamed Eddouks
Affiliations

Effect of the desert plant Retama raetam on glycaemia in normal and streptozotocin-induced diabetic rats

Mhamed Maghrani et al. J Ethnopharmacol. 2003 Jul.

Abstract

The effect of the aqueous extract of Retama raetam (RR) on blood glucose levels was investigated in fasting normal and streptozotocin-induced diabetic rats after single and repeated oral administration. The aqueous extract of RR at a dose of 20mg/kg significantly reduced the blood glucose in normal rats 6h after a single oral administration (P<0.005) and two weeks after repeated oral administration (P<0.05). This hypoglycaemic effect is more pronounced in streptozotocin (STZ) diabetic rats (P<0.001). The aqueous extract of RR had no effect on basal plasma insulin levels indicating that the underlying mechanism of RR activity is extra-pancreatic. These findings suggest that the aqueous extract of RR possess significant hypoglycaemic effect in both normal and STZ diabetic rats.

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