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Comment
. 2003 Jun;21(6):244-7.
doi: 10.1016/S0167-7799(03)00089-1.

Synthetic gene libraries: in search of the optimal diversity

Marc Ostermeier  1
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Synthetic gene libraries: in search of the optimal diversity

Marc Ostermeier. Trends Biotechnol. 2003 Jun.

Abstract

Directed evolution has proven to be an effective method for evolving proteins with desired properties. A key step is the creation of suitably diverse gene libraries. Two new methods for creating such libraries make sole use of synthesized oligonucleotides and allow researchers to tailor the diversity of a library with greater precision and create libraries with greater diversity than was previously possible. Such increased diversity appears to accelerate directed evolution.

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