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Case Reports
. 2003 Jun 5:3:2.
doi: 10.1186/1472-6904-3-2.

Piperacillin induced bone marrow suppression: a case report

Ashish Kumar  1 , Gourdas Choudhuri, Rakesh Aggarwal
Affiliations
Case Reports

Piperacillin induced bone marrow suppression: a case report

Ashish Kumar et al. BMC Clin Pharmacol. .

Abstract

Background: Piperacillin (and piperacillin/tazobactam) is a commonly prescribed antibiotic and is generally considered safe. We report a case of piperacillin induced bone marrow suppression.

Case presentation: A 19-year-old boy was being treated with piperacillin followed by piperacillin/tazobactam for infected pancreatic pseudocyst. After 21 days of treatment, he developed neutropenia and thrombocytopenia. These reversed promptly after stopping piperacillin/tazobactam. The time course of events suggested that piperacillin was the cause of bone marrow suppression in this patient.

Conclusion: Bone marrow suppression is a serious adverse effect of piperacillin, which should be kept in mind while treating patients with this drug.

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