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. 2003 Jun;41(6):2659-61.
doi: 10.1128/JCM.41.6.2659-2661.2003.

Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Daniel J Diekema  1 , Janet I Andrews, Holly Huynh, Paul R Rhomberg, Stella R Doktor, Jill Beyer, Virginia D Shortridge, Robert K Flamm, Ronald N Jones, Michael A Pfaller
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Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Daniel J Diekema et al. J Clin Microbiol. 2003 Jun.

Abstract

Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.

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Figures

FIG. 1.
FIG. 1.
PFGE patterns of neonatal bloodstream isolates of GBS-V. Lanes 1, 8, and 15, lambda ladder control; lanes 2 to 7 and 9 to 14, patterns of 12 different isolates (see Table 2 for descriptions of individual isolates). Lane 2 shows the pattern of a strain provided by the CDC and found to be the most common pattern of GBS-V in surveillance studies performed in the United States between 1986 and 1996 (6).
See this image and copyright information in PMC

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