Review
doi: 10.1188/03.CJON.313-319.
Ecteinascidin-743
Affiliations
- PMID: 12793338
- DOI: 10.1188/03.CJON.313-319
Item in Clipboard
Review
Ecteinascidin-743
Clin J Oncol Nurs.
2003 May-Jun.
Abstract
Ecteinascidin-743 (ET-743) is a marine-derived antineoplastic agent undergoing clinical trials to evaluate its use in the treatment of a variety of solid tumors. After the completion of the phase I studies, the agent subsequently was investigated in phase II trials for efficacy in a variety of tumor types. Ongoing phase I evaluation continues with other antineoplastic agents. Side effects of ET-743 include myelosuppression, hepatotoxicity, and nausea and vomiting. Liver function test monitoring is crucial and useful in predicting other serious toxicities. Nursing care issues and patient education are discussed in this article.
Similar articles
-
Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues.J Nat Prod. 2008 Mar;71(3):409-14. doi: 10.1021/np800022x. Epub 2008 Feb 16. J Nat Prod. 2008. PMID: 18278868
-
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata.Biochemistry. 1996 Oct 15;35(41):13303-9. doi: 10.1021/bi960306b. Biochemistry. 1996. PMID: 8873596
-
Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action.Anticancer Drugs. 2002 Jul;13(6):545-55. doi: 10.1097/00001813-200207000-00001. Anticancer Drugs. 2002. PMID: 12172500 Review.
-
Ecteinascidin-743 (ET-743): early test or effective treatment in soft tissue sarcomas?J Clin Oncol. 2005 Aug 20;23(24):5420-3. doi: 10.1200/JCO.2005.04.905. J Clin Oncol. 2005. PMID: 16109999 No abstract available.
-
[Ecteinascidin 743].Bull Cancer. 1999 Feb;86(2):139-41. Bull Cancer. 1999. PMID: 10094523 Review. French. No abstract available.
Cited by
-
Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update.Arch Toxicol. 2021 Feb;95(2):395-472. doi: 10.1007/s00204-020-02971-4. Epub 2021 Jan 18. Arch Toxicol. 2021. PMID: 33459808 Free PMC article. Review.
-
The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects.J Trop Med. 2022 Oct 10;2022:5919453. doi: 10.1155/2022/5919453. eCollection 2022. J Trop Med. 2022. PMID: 36263439 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
