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. 2003 Jun;6(3):153-62.
doi: 10.1080/1028415031000111282.

Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model

J A Joseph  1 , N A Denisova, G Arendash, M Gordon, D Diamond, B Shukitt-Hale, D Morgan
Affiliations

Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model

J A Joseph et al. Nutr Neurosci. 2003 Jun.

Abstract

Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP + PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.

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