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Review
. 2003 Apr;20(2):203-6.
doi: 10.1385/JMN:20:2:203.

The relationship between amyloid and tau

John Hardy  1
Affiliations
Review

The relationship between amyloid and tau

John Hardy. J Mol Neurosci. 2003 Apr.

Abstract

Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

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