Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene
Affiliations
- PMID: 1279499
Item in Clipboard
Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene
Oncogene.
1992 Nov.
Abstract
We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.
Similar articles
-
Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III.Oncogene. 1992 Apr;7(4):685-91. Oncogene. 1992. PMID: 1373482
-
Deletion of the KIT and PDGFRA genes in a patient with piebaldism.Am J Med Genet. 1992 Nov 1;44(4):492-5. doi: 10.1002/ajmg.1320440422. Am J Med Genet. 1992. PMID: 1279971
-
Cloning and structural analysis of the human c-kit gene.Oncogene. 1992 Jul;7(7):1259-66. Oncogene. 1992. PMID: 1377810
-
A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.Genomics. 1994 Jul 15;22(2):431-6. doi: 10.1006/geno.1994.1405. Genomics. 1994. PMID: 7528718
-
Molecular analysis of the ets genes and their products.Crit Rev Oncog. 1990;1(4):409-36. Crit Rev Oncog. 1990. PMID: 1964597 Review.
Cited by
-
Recent Advances in the Molecular Biology of Systemic Mastocytosis: Implications for Diagnosis, Prognosis, and Therapy.Int J Mol Sci. 2020 Jun 2;21(11):3987. doi: 10.3390/ijms21113987. Int J Mol Sci. 2020. PMID: 32498255 Free PMC article. Review.
-
Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function.Exp Hematol. 2007 Feb;35(2):214-220. doi: 10.1016/j.exphem.2006.10.001. Exp Hematol. 2007. PMID: 17258070 Free PMC article.
-
Involvement of stem cell factor and c-kit in corneal wound healing in mice.Mol Vis. 2012;18:1505-15. Epub 2012 Jun 7. Mol Vis. 2012. PMID: 22736941 Free PMC article.
-
Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene.Immunology. 2003 Jan;108(1):89-97. doi: 10.1046/j.1365-2567.2003.01559.x. Immunology. 2003. PMID: 12519307 Free PMC article.
-
Tyrosine-kinase mutations in c-KIT and PDGFR-alpha genes of imatinib naïve adult patients with gastrointestinal stromal tumours (GISTs) of the stomach and small intestine: relation to tumour-biological risk-profile and long-term outcome.Clin Transl Oncol. 2012 Aug;14(8):619-29. doi: 10.1007/s12094-012-0851-x. Epub 2012 Jul 18. Clin Transl Oncol. 2012. PMID: 22855146
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Miscellaneous