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. 1992 Nov;7(11):2207-17.

Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene

L B Giebel  1 , K M Strunk, S A Holmes, R A Spritz
Affiliations
  • PMID: 1279499

Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene

L B Giebel et al. Oncogene. 1992 Nov.

Abstract

We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.

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