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Clinical Trial
. 2003 Jun 10;60(11):1849-51.
doi: 10.1212/01.wnl.0000071218.34009.af.

Longitudinal MRI study: the effects of azathioprine in MS patients refractory to interferon beta-1b

S Markovic-Plese  1 , B Bielekova, N Kadom, T P Leist, R Martin, J A Frank, H F McFarland
Affiliations
Clinical Trial

Longitudinal MRI study: the effects of azathioprine in MS patients refractory to interferon beta-1b

S Markovic-Plese et al. Neurology. .

Abstract

An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon beta-1b (IFNbeta-1b) in patients with treatment-refractory relapsing-remitting MS. Six IFNbeta-1b-treated MS patients with continued disease activity were studied on IFNbeta-1b and AZA therapy for a median period of 15 months. A 69% reduction in the number of contrast-enhancing lesions was observed during the combination therapy (p = 0.002).

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