Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Nov 1;89(21):10036-40.
doi: 10.1073/pnas.89.21.10036.

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas

D E Picarella  1 , A Kratz, C B Li, N H Ruddle, R A Flavell
Affiliations

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas

D E Picarella et al. Proc Natl Acad Sci U S A. .

Abstract

Tumor necrosis factor beta (TNF-beta) (lymphotoxin) may play an important role in the immune response and pathologic inflammatory diseases. Insulitis is an important early step in the development of insulin-dependent diabetes mellitus. To understand better the role of TNF-beta in the regulation of inflammation and type 1 diabetes, we produced transgenic mice in which the murine TNF-beta gene was regulated by the rat insulin II promoter. The transgene was expressed in the pancreas, kidney, and skin of transgenic mice. The expression of TNF-beta in the pancreas of transgenic mice resulted in a leukocytic inflammatory infiltrate consisting primarily of B220+ IgM+ B cells and CD4+ and CD8+ T cells. The insulitis is reminiscent of the early stages of diabetes, though the mice did not progress to diabetes.

PubMed Disclaimer

References

    1. Immunol Rev. 1991 Oct;123:115-44 - PubMed
    1. J Cell Biol. 1983 May;96(5):1337-54 - PubMed
    1. Diabetes. 1991 May;40(5):648-51 - PubMed
    1. Nature. 1991 Sep 19;353(6341):260-2 - PubMed
    1. Nature. 1990 Aug 30;346(6287):844-7 - PubMed

Publication types

MeSH terms