Fractional derivatives embody essential features of cell rheological behavior

Abstract

Mechanical moduli of cultured airway smooth muscle cells (Fabry, B., et al. Phys. Rev. Lett. 87:148102, 2001) reveal that the frequency dependence of cell rheological behavior conforms to a weak power-law relationship over a wide range of frequency (10(-2)-10(3) Hz). Such a behavior cannot be accounted for by standard viscoelastic models characterized by a discrete number of time constants that have been commonly used in previous studies of cell viscoelasticity. Fractional calculus, by contrast, provides a natural framework for describing weak power-law relationships and requires no assumptions about the type of material, the time constant distribution or the time/frequency interval in which rheological observations are made. In this study, we developed a rheological model of the cell using methods of fractional calculus. We used a least-squares technique to fit the model to data previously obtained from measurements on airway smooth muscle cells. The fit provided an excellent correspondence to the data, and the estimated values of model parameters were physically plausible. The model leads to a novel and unexpected empirical link between dynamic viscoelastic behavior of the cytoskeleton and the static contractile stress that it bears.