Review
doi: 10.1016/s0896-6273(03)00329-5.
Together at last: bHLH and LIM-HD regulators cooperate to specify motor neurons
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- PMID: 12797950
- DOI: 10.1016/s0896-6273(03)00329-5
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Review
Together at last: bHLH and LIM-HD regulators cooperate to specify motor neurons
Neuron.
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Free article
Abstract
bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between these factors functions to synchronize neurogenesis with neuronal cell type specification.
Comment on
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Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors.Neuron. 2003 Jun 5;38(5):731-45. doi: 10.1016/s0896-6273(03)00296-4. Neuron. 2003. PMID: 12797958
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