doi: 10.1016/s0960-894x(03)00298-1.
Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors
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- PMID: 12798340
- DOI: 10.1016/s0960-894x(03)00298-1
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Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors
Bioorg Med Chem Lett.
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Abstract
Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.
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