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. 2003 Jul 7;13(13):2231-4.
doi: 10.1016/s0960-894x(03)00298-1.

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

John Finn  1 , Karen Mattia, Mike Morytko, Siya Ram, Yingfei Yang, Ximao Wu, Elsa Mak, Paul Gallant, Dennis Keith
Affiliations

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

John Finn et al. Bioorg Med Chem Lett. .

Abstract

Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significantly improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase.

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