Comparative Study
doi: 10.1016/0041-0101(92)90439-c.
Comparative characterization of two toxic phospholipases A2 from Indian cobra (Naja naja naja) venom
Affiliations
- PMID: 1279838
- DOI: 10.1016/0041-0101(92)90439-c
Item in Clipboard
Comparative Study
Comparative characterization of two toxic phospholipases A2 from Indian cobra (Naja naja naja) venom
Toxicon.
1992 Oct.
Abstract
Indian cobra venom contains many phospholipase A2 (PLA2) toxins. In the present study two toxic PLA2s have been purified from the Indian cobra (Naja naja naja) venom by column chromatography. The NN-XIa-and NN-XIb-PLA2s have mol. wts between 10,700 and 15,000. The NN-XIa-PLA2 induces myotoxic effects, oedema and neurotoxicity in mice and has an i.p. LD50 of 8.5 mg/kg body weight. The NN-XIa-PLA2 is also cytotoxic to Ehrlich ascites tumour cells. The other PLA2, NN-XIb, in contrast has an i.p. LD50 of 0.22 mg/kg body weight, and it induces acute neurotoxicity. The NN-XIb-PLA2 is devoid of the other biological activities which are exhibited by NN-XIa-PLA2.
Similar articles
-
Immunochemical cross-reactivity of neurotoxic phospholipase A2 enzymes from Indian cobra (Naja naja naja) venom using polyclonal antibodies.Toxicon. 1993 Sep;31(9):1167-77. doi: 10.1016/0041-0101(93)90132-3. Toxicon. 1993. PMID: 7505490
-
Purification and characterization of a neurotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom.Toxicon. 1991;29(11):1345-9. doi: 10.1016/0041-0101(91)90121-7. Toxicon. 1991. PMID: 1814010
-
Purification and characterization of a myotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom.Toxicon. 1989;27(8):861-73. doi: 10.1016/0041-0101(89)90098-6. Toxicon. 1989. PMID: 2781585
-
Purification and characterization of three acidic, cytotoxic phospholipases A2 from Indian cobra (Naja naja naja) venom.Toxicon. 1998 Jun;36(6):921-32. doi: 10.1016/s0041-0101(97)00097-4. Toxicon. 1998. PMID: 9663698
-
Exploring the structural and functional aspects of the phospholipase A2 from Naja spp.Int J Biol Macromol. 2019 Nov 1;140:49-58. doi: 10.1016/j.ijbiomac.2019.08.125. Epub 2019 Aug 14. Int J Biol Macromol. 2019. PMID: 31421173 Review.
Cited by
-
Hypothesis of snake and insect venoms against Human Immunodeficiency Virus: a review.AIDS Res Ther. 2009 Nov 19;6:25. doi: 10.1186/1742-6405-6-25. AIDS Res Ther. 2009. PMID: 19922674 Free PMC article.
-
Biomedical applications of snake venom: from basic science to autoimmunity and rheumatology.J Transl Autoimmun. 2020 Dec 14;4:100076. doi: 10.1016/j.jtauto.2020.100076. eCollection 2021. J Transl Autoimmun. 2020. PMID: 33385156 Free PMC article. Review.
-
Strong myotoxic activity of Trimeresurus malabaricus venom: role of metalloproteases.Mol Cell Biochem. 2006 Jan;282(1-2):147-55. doi: 10.1007/s11010-006-1738-3. Mol Cell Biochem. 2006. PMID: 16317522
-
Antitumor effect of Bothrops jararaca venom.Mediators Inflamm. 2002 Apr;11(2):99-104. doi: 10.1080/09629350220131953. Mediators Inflamm. 2002. PMID: 12061431 Free PMC article.