Inhibitory effects of tetrandrine on Bay k 8644-stimulated contraction of isolated rabbit aortic strips
Affiliations
- PMID: 1279938
Item in Clipboard
Inhibitory effects of tetrandrine on Bay k 8644-stimulated contraction of isolated rabbit aortic strips
Zhongguo Yao Li Xue Bao.
1992 May.
Free article
Abstract
In the presence of KCl 19 mmol.L-1, calcium agonist Bay k 8644 0.47 mumol.L-1 elicited a strong contraction of isolated rabbit aortic strips, and this contraction was concentration-dependently inhibited by tetrandrine; but this antagonism was noncompetitive. Calcium ionophore calcimycin evoked contraction was markedly depressed by tetrandrine. The results suggested that tetrandrine might not only inhibit transmembrane influx of calcium via potential-dependent channels but also interfere with other processes related to calcium.
Similar articles
-
Tetrandrine is not a selective calcium channel blocker in vascular smooth muscle.Zhongguo Yao Li Xue Bao. 1992 Sep;13(5):385-90. Zhongguo Yao Li Xue Bao. 1992. PMID: 1300036
-
[Effects of tetrandrine on cytosolic free calcium in fetal rat cerebral cells].Yao Xue Xue Bao. 1994;29(7):492-6. Yao Xue Xue Bao. 1994. PMID: 7526598 Chinese.
-
Endothelin-1-induced vascular contractions: interactions with drugs affecting the calcium channel.J Cardiovasc Pharmacol. 1989;13 Suppl 5:S63-6; discussion S74. J Cardiovasc Pharmacol. 1989. PMID: 2473330
-
Herbal alkaloid tetrandrine: fron an ion channel blocker to inhibitor of tumor proliferation.Trends Pharmacol Sci. 2004 Mar;25(3):120-3. doi: 10.1016/j.tips.2004.01.009. Trends Pharmacol Sci. 2004. PMID: 15058281 Review. No abstract available.
-
Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs.Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S297-9. doi: 10.1111/j.1440-1681.1995.tb02925.x. Clin Exp Pharmacol Physiol Suppl. 1995. PMID: 9072399 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
