Transcription and the territory: the ins and outs of gene positioning

Abstract

When cells exit mitosis, the neat rod-like chromosomes decondense into their interphase state. However, the chromatin threads are not randomly dispersed throughout the nucleoplasm. Rather, individual chromosomes appear to be organized into discrete, non-overlapping "territories". Current studies attempt to unravel how gene loci are organized within these territories, whether their subterritorial positions are dependent on transcription, and the extent to which the loci can move.