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. 2003 May;142(5):342-4, 398.

[The effect of time on the perception of dyspnea following inhaled long-acting bronchodilator]

[Article in Hebrew]
Paltiel Weiner  1 , Rasmi Magadle, Marinella Beckerman, Noa Berar-Yanay
Affiliations
  • PMID: 12803056

[The effect of time on the perception of dyspnea following inhaled long-acting bronchodilator]

[Article in Hebrew]
Paltiel Weiner et al. Harefuah. 2003 May.

Abstract

Study objectives: To assess the effect of time on the change in the perception of dyspnea (POD) following inhalation of long-acting bronchodilator.

Patients and methods: Spirometry and the POD were measured in 32 asthmatic patients, with moderate asthma, before and following inhalation of placebo, and salmeterol. The POD was measured while breathing against progressive loads, using a visual analogue scale (VAS).

Results: The highest FEV1 levels and the lowest POD were measured one hour after salmeterol inhalation. Although the mean FEV1 remained close to its peak value for at least six hours following the inhalation of salmeterol, there was a gradual statistically significant increase in the POD.

Conclusions: Following inhalation of long-acting bronchodilator (LABD) there is relationship between the increase in the FEV1 and the decrease in POD. With time there is a gradual increase in the perception of dyspnea regardless of the FEV1.

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