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Multicenter Study
. 2003 Jul;34(7):e79-81.
doi: 10.1161/01.STR.0000078309.56307.5C. Epub 2003 Jun 12.

Infection and the risk of spontaneous cervical artery dissection: a case-control study

Benoît Guillon  1 , Karine Berthet, Lamia Benslamia, Marion Bertrand, Marie-Germaine Bousser, Christophe Tzourio
Affiliations
Multicenter Study

Infection and the risk of spontaneous cervical artery dissection: a case-control study

Benoît Guillon et al. Stroke. 2003 Jul.

Abstract

Background and purpose: Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study.

Methods: Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event.

Results: Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection.

Conclusions: Recent infection is a risk factor and could be a trigger for SCAD.

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