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. 2003 Jun 13;300(5626):1701-3.
doi: 10.1126/science.1085371.

Evolution of the protein repertoire

Cyrus Chothia  1 , Julian Gough, Christine Vogel, Sarah A Teichmann
Affiliations

Evolution of the protein repertoire

Cyrus Chothia et al. Science. .

Abstract

Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

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