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Review
. 2003 Jul;109(3):319-25.
doi: 10.1046/j.1365-2567.2003.01678.x.

The peripheral generation of CD4+ CD25+ regulatory T cells

Arne N Akbar  1 , Leonie S Taams, Mike Salmon, Milica Vukmanovic-Stejic
Affiliations
Review

The peripheral generation of CD4+ CD25+ regulatory T cells

Arne N Akbar et al. Immunology. 2003 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Model for the generation of CD4+ CD25+ regulatory T cells in the periphery. Naïve CD4+ T cells become primed upon encounter with antigen on antigen-presenting cells, lose CD45RA and acquire CD45RO expression. These cells remain CD45RBhigh during this process and retain the capacity to secrete large amounts of IL-2. They still express Bcl-2 and have long telomeres. Repeated stimulation of the primed cells by frequently encountered antigen leads to generation of highly differentiated CD4+ CD45RO+ CD45RBlow memory/effector T cells. These highly differentiated T cells have short telomeres and are prone to apoptosis, as they express low levels of Bcl-2. They also have a profoundly diminished ability to secrete IL-2, which makes them susceptible to anergy induction. These cells can either remain as effector T cells, or they can become anergised and acquire suppressive capacity.
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