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Review
. 2003 Jul;89(7):801-5.
doi: 10.1136/heart.89.7.801.

Calcific aortic stenosis: from bench to the bedside--emerging clinical and cellular concepts

Nalini M Rajamannan  1 , Bernard Gersh, Robert O Bonow
Affiliations
Review

Calcific aortic stenosis: from bench to the bedside--emerging clinical and cellular concepts

Nalini M Rajamannan et al. Heart. 2003 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Calcified human aortic valve removed at the time of valve replacement. The arrow points to the bone-like nodules on the aortic surface of the aortic valve. The leaflets also demonstrate increase in thickening.
Figure 2
Figure 2
Normal versus hypercholesterolaemic aortic valve. The valve leaflet of the normal aortic valve (panel A1) has a clear glistening appearance, which is attached to the aorta. The hypercholesterolaemic aortic valve (panel A2) shows atherosclerotic lipid deposition on the valve leaflet as well as the vascular aorta.
Figure 3
Figure 3
Possible mechanism for the development of aortic valve calcification. The cell within the valve develops osteoblast-like features which synthesise important bone matrix proteins involved in the calcification process in the valve.
See this image and copyright information in PMC

References

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