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. 2003 May;8(5):485-7.
doi: 10.1038/sj.mp.4001348.

Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

N M Williams  1 , A Preece, G Spurlock, N Norton, H J Williams, S Zammit, M C O'Donovan, M J Owen
Affiliations

Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia

N M Williams et al. Mol Psychiatry. 2003 May.

Abstract

Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype that was significantly over-represented in schizophrenic individuals compared to controls (15.4 : 7.5%, P=6.7 x 10(-6)). We have attempted to replicate this result in our large collection of 573 schizophrenia cases and 618 controls. We found that the risk haplotype was more common in cases than controls (9.5 : 7.5%; P=0.04), and especially in our subset of 141 cases with a family history of schizophrenia (11.6%; P=0.019). Our results therefore replicate the Icelandic findings in an out-bred Northern European population, although they suggest that the risk conferred by the haplotype is small.

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Comment in

  • Neuregulin 1 in schizophrenia: out of Iceland.
    Stefánsson H, Thorgeirsson TE, Gulcher JR, Stefánsson K. Stefánsson H, et al. Mol Psychiatry. 2003 Jul;8(7):639-40. doi: 10.1038/sj.mp.4001384. Mol Psychiatry. 2003. PMID: 12874596 No abstract available.