Review
T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis
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- PMID: 1280847
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Review
T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis
Rheum Dis Clin North Am.
1992 Nov.
Abstract
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
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