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Review
. 1992 Nov;18(4):793-807.

T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis

P K Gregersen  1
Affiliations
  • PMID: 1280847
Review

T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis

P K Gregersen. Rheum Dis Clin North Am. 1992 Nov.

Abstract

Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.

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