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Clinical Trial
. 2003 Jun-Jul;21(6):293-5.
doi: 10.1016/s0213-005x(03)72943-7.

[Directly observed treatment of latent tuberculosis infection: comparative study of two isoniazid regimens]

[Article in Spanish]
Joaquín Portilla  1 , Pilar Jordá, Javier Esteban, José Sánchez-Payá, Esperanza Merino, Vicente Boix; Grupo de Estudio Protocolo-INH
Affiliations
Clinical Trial

[Directly observed treatment of latent tuberculosis infection: comparative study of two isoniazid regimens]

[Article in Spanish]
Joaquín Portilla et al. Enferm Infecc Microbiol Clin. 2003 Jun-Jul.

Abstract

Introduction: To compare compliance with two isoniazid regimens in drug users with latent tuberculosis infection. METHODS.

Design: clinical trial. Group 1: isoniazid 300 mg once daily (16 patients); Group 2: isoniazid 900 mg/twice weekly (21).

Endpoints: compliance, toxicity and efficacy.

Results: Group 1 vs. Group 2: continuation in program 81/82% (p 5 NS), compliance full doses 43.7/66.6% (p 5 0.1), median percentage of days not taking isoniazid: 1.8 (0.2-4.3) vs. 0 (0-1.7) (p 5 0.06).

Conclusions: Compliance was high in both therapeutic arms. The twice-weekly isoniazid regimen favored compliance, but differences were not significant.

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