Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2003 Jun 24;100(13):7428-9.
doi: 10.1073/pnas.1432875100. Epub 2003 Jun 16.

Replication of the herpes simplex virus genome: does it really go around in circles?

Rozanne M Sandri-Goldin  1
Affiliations
Comment

Replication of the herpes simplex virus genome: does it really go around in circles?

Rozanne M Sandri-Goldin. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Schematic representation of the HSV-1 genome showing the unique long region (UL) bounded by a terminal repeat region (TRL) and an inverted internal repeat region (IRL). The unique short region (US) is similarly bounded by a terminal repeat region (TRS) and an inverted internal repeat region (IRS). The three origins of DNA replication, oriL and two copies of oriS, are shown. Jackson and DeLuca (16) have shown that, in the absence of ICP0, the genome circularizes and persists. When ICP0 is expressed very early during infection, the genome replicates and both linear and concatemeric replication forms are detected. Thus, these authors suggest that ICP0 regulates circle formation, and that circle formation may lead to latency, whereas DNA replication during productive infection prefers a linear template.
See this image and copyright information in PMC

Comment on

References

    1. Deshmane, S. L. & Fraser, N. W. (1989) J. Virol. 63, 943–947. - PMC - PubMed
    1. Preston, C. M. (2000) J. Gen. Virol. 81, 1–19. - PubMed
    1. Cai, W., Astor, T. L., Liptak, L. M., Cho, C., Coen, D. M. & Schaffer, P. A. (1993) J. Virol. 67, 7501–7512. - PMC - PubMed
    1. Clements, G. B. & Stow, N. D. (1989) J. Gen. Virol. 70, 2501–2506. - PubMed
    1. Leib, D. A., Coen, D. M., Bogard, C. L., Hicks, J. B., Yager, D. R., Knipe, D. M., Tyler, K. L. & Schaffer, P. A. (1989) J. Virol. 63, 759–768. - PMC - PubMed

LinkOut - more resources