Nitroheterocyclic drugs with broad spectrum activity
- PMID: 12811546
- DOI: 10.1007/s00436-002-0754-9
Nitroheterocyclic drugs with broad spectrum activity
Abstract
The group of biologically active nitroheterocyclic compounds includes various 5- and 2-nitroimidazoles and 5-nitrofurans, which can be used as therapeutic agents against a variety of protozoan and bacterial (anaerobic) infections of humans and animals. The current status in the the treatment of giardiasis, trichomoniasis, balantidiasis, histomoniasis, and amebiasis (including infections due to opportunistic amebas) is presented. The most relevant drugs (benznidazole, furazolidone, metronidazole, misonidazole, nifurtimox, nimorazole, nitazoxanide, ornidazole, secnidazole, and tinidazole) are characterized with regard to their chemical, chemotherapeutic, toxicological, pharmacokinetic, and pharmacological properties, including the mechanism of action and resistance in certain parasitic protozoa.
Similar articles
-
[Testing of preparations against histomoniasis in turkeys].Veterinariia. 1971 Feb;2:81. Veterinariia. 1971. PMID: 5166295 Russian. No abstract available.
-
The metabolic activation of nitroheterocyclic therapeutic agents.Drug Metab Rev. 1988;19(1):33-62. doi: 10.3109/03602538809049618. Drug Metab Rev. 1988. PMID: 3293954 Review. No abstract available.
-
Chemotherapeutic properties of heterocyclic compounds: monocyclic compounds with five-membered rings.Annu Rev Microbiol. 1973;27:317-46. doi: 10.1146/annurev.mi.27.100173.001533. Annu Rev Microbiol. 1973. PMID: 4584690 Review. No abstract available.
-
[Chemotherapy of some protozoan infections (leishmaniasis, trichomoniasis, lambliosis, toxoplasmosis). (Review)].Farmakol Toksikol. 1969 May-Jun;32(3):342-56. Farmakol Toksikol. 1969. PMID: 4897615 Review. Russian. No abstract available.
-
Nitroimidazoles in the treatment of trichomoniasis, giardiasis, and amebiasis.Int J Clin Pharmacol Ther Toxicol. 1984 Feb;22(2):63-72. Int J Clin Pharmacol Ther Toxicol. 1984. PMID: 6698665
Cited by
-
Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review.Antibiotics (Basel). 2023 Sep 29;12(10):1495. doi: 10.3390/antibiotics12101495. Antibiotics (Basel). 2023. PMID: 37887196 Free PMC article. Review.
-
In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series.Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):81-86. doi: 10.1016/j.ijpddr.2018.01.006. Epub 2018 Jan 31. Int J Parasitol Drugs Drug Resist. 2018. PMID: 29425734 Free PMC article.
-
4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle.Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):120-129. doi: 10.1016/j.ijpddr.2017.02.002. Epub 2017 Feb 21. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28285258 Free PMC article.
-
Novel quinazolines bearing 1,3,4-thiadiazole-aryl urea derivative as anticancer agents: design, synthesis, molecular docking, DFT and bioactivity evaluations.BMC Chem. 2024 Feb 12;18(1):30. doi: 10.1186/s13065-024-01119-0. BMC Chem. 2024. PMID: 38347613 Free PMC article.
-
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.PLoS Med. 2006 Nov;3(11):e466. doi: 10.1371/journal.pmed.0030466. PLoS Med. 2006. PMID: 17132069 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
