Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jul;87(7):853-5.
doi: 10.1136/bjo.87.7.853.

Long term visual outcome of patients with cytomegalovirus retinitis treated with highly active antiretroviral therapy

D E Goldberg  1 , H Wang, S P Azen, W R Freeman
Affiliations

Long term visual outcome of patients with cytomegalovirus retinitis treated with highly active antiretroviral therapy

D E Goldberg et al. Br J Ophthalmol. 2003 Jul.

Abstract

Background: Healed cytomegalovirus (CMV) retinitis in the setting of highly active antiretroviral therapy (HAART) is complicated by inflammatory sequelae and vision loss.

Aim: To determine the long term visual outcome of AIDS patients with CMV retinitis who received HAART.

Methods: 90 eyes of 63 consecutive AIDS patients with extramacular CMV retinitis were studied prospectively.

Results: Immune recovery status was related to time to onset of epiretinal membrane (p=0.05) and cystoid macular oedema (p=0.06) as well as to the incidence of cataract (p=0.001) and moderate vision loss (p<0.0001). Severe vision loss was associated with retinal detachment (p<0.001).

Conclusion: AIDS patients with extramacular CMV retinitis lose vision while on HAART. HAART related immune recovery is associated with increased frequencies of epiretinal membrane, cystoid macular oedema, cataract, and retinal detachment with resultant vision loss in AIDS patients with healed CMV retinitis.

PubMed Disclaimer

References

    1. Mitchell SM, Membrey WL, Youle MS, et al. Cytomegalovirus retinitis after the initiation of highly active antiretroviral therapy: a 2-year prospective study. Br J Ophthalmol 1999; 83:652–5. - PMC - PubMed
    1. Macdonald JC, Karavellas MP, Torriani FJ, et al. Highly active antiretroviral therapy-related immune recovery in AIDS patients with cytomegalovirus retinitis. Ophthalmology 2000;107:877–83. - PubMed
    1. Karavellas, MP, Plummer DJ, Macdonald JC, et al. Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy. J Infect Dis 1999;179:697–700. - PubMed
    1. Holland GN. Immune recovery uveitis. Ocular Inflamm 1999;7:215–21. - PubMed
    1. Nguyen QD, Kempen JH, Bolton SG, et al. Immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis after highly active antiretroviral therapy. Am J Ophthalmol 2000;129:634–9. - PubMed

Publication types